Sleep, performance, and circadian rhythm data will be compared to those collected by their team and others during previous flight missions aboard ISS, in addition to surveillance of medical and psychological health in collaboration with mission flight surgeons. Since the onset of the SSLA retrofit, the investigators have started the inflight ISS study to assess the acceptability, use, and impact of deployment of a dynamic lighting schedule aboard the ISS during operational flight missions on astronaut vision, sleep, alertness, circadian rhythms, and general well-being. Since then, a total of 51 SSLAs have been installed on ISS, bringing the total retrofit to 60% replacement of GLAs on the US portion of ISS. In addition, the initial SSLA was installed on ISS in 2016. Specifically, standardized psychometric, physiological, and neurobehavioral measures are testing the efficacy of light from the SSLAs to improve vision, circadian regulation, sleep, and performance in healthy astronaut-aged subjects. This research is comprised of a multidisciplinary collaboration between Thomas Jefferson University, Brigham and Women's Hospital, and JSC to complete a ground-based study in a high fidelity analog of the crew sleeping quarters and daily living environment of the ISS. NASA ordered and received for a set of SSLAs intended to have this dual capacity. The Principal Investigator and Co-Principal Investigator of the intended research worked with engineers, scientists, and managers from Johnson Space Center (JSC) to revise the SSLA specifications so that the new lighting units would have dual capacity to: 1) provide illumination for crew members' working and living quarters, and 2) serve as a lighting countermeasure for crewmembers' circadian and sleep disruption. Engineers at Kennedy Space Center developed a prototype Solid-State Lighting Assembly (SSLA) that was successfully installed onboard the ISS during ISS Expedition 18. NASA has determined that, beginning in 2016, the GLAs would be replaced with Solid-State Light Assemblies (SSLAs) containing Light Emitting Diodes (LEDs). The SSLAs should be studied in a high fidelity ground analog environment, then implemented on ISS to evaluate individual crewmember outcomes related to circadian physiology, sleep, behavioral health and performance using sensitive and validated measures that are feasible in the spaceflight environment."Ĭurrently, the International Space Station (ISS) uses General Luminaire Assemblies (GLAs) that house fluorescent lamps for illuminating the astronauts' working and living environments. This research addresses the NASA Research Announcement (NRA) NNJ13ZSA002N-BMED: Behavioral Health and Human Performance: "Evaluation of the Neurobehavioral Effects of a Dynamic Lighting System on the ISS." This NRA solicited both "Ground Based and Flight-Definition" research with the specific instructions that the "ground study serves as a precursor to the flight study, therefore the ground study should take place in an analog with high fidelity to the ISS.
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